图片文题:Dose response and time course of manganese-enhanced magnetic resonance imaging for visual pathw

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图片介绍

Figure 1 MRI images 24 hours after intravitreal injection with various concentrations of MnCl2 (2–40 mM).


Figure 2 Positive correlation between optic nerve SNR and MnCl2 concentration.


Figure 3 Time course of SNR in the optic nerve after intravitreal injection of different concentrations of MnCl2.


Figure 4 MRI of the visual pathway at various time points after intravitreal injection of 20 mM MnCl2.


图片来源

Wei-ling Wang, Hui Xu, Ying Li, Zhi-zhong Ma, Xiao-dong Sun, Yun-tao Hu. Dose response and time course of manganese-enhanced magnetic resonance imaging for visual pathway tracing in vivo [J]. Neural Regeneration Research, 2016, 11(7): 1185-1190.


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文章摘要

轴索示踪可以有效检测视神经的损伤和再生,但既往采用的组织学方法不能观察到神经轴浆流和突触传递动态过程。锰离子增强磁共振成像(MEMRI)可有效进行活体视神经示踪。作者实验中将不同浓度的MnCl2注射至兔左眼玻璃体,注射后MRI观察应用不同时间后兔视觉通路的成像发生了变化。结果发现2 mM的MnCl2即可使视神经显像增强,但外侧膝状体和上丘脑的图像没有变化,而5-40mM的MnCl2可使视网膜投射到对侧上丘的视觉通路的信号显著增强,但2-40 mM的MnCl2都没能使大脑视觉皮质中的信号增强。注射MnCl2后24h图像增强最为显著,而24h-7d时信号逐渐减弱。由结果可知,锰离子增强磁共振图像是活体示踪视神经的一种可行方法,信号强度与Mn2+玻璃体腔注射的剂量有关,且最强的信号出现在玻璃体内注射后24 h。


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http://www.sjzsyj.org/CN/article/openArticlePDF.jsp?id=1946