American Journal of Therapeutics 美国治疗学杂志
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Types of Articles
American Journal of Therapeutics publishes Original Investigations, Meta-analyses, Brief Reports, Therapeutic Challenges, Systematic Reviews and Clinical Guidelines.

Original Investigation
These reports include clinical trials, cohort and case-control studies, risk-benefit assessments, and clinical decision analyses. The text (excluding the title page, tables and references) should not exceed 3000 words. A structured Abstract of 300 words is required and should include the following paragraphs: Background, Study Question, Study Design, Measures and Outcomes, Results, and Conclusions.

Meta-analysis
The data sources must be described in detail and should include in formation published during the year of manuscript preparation. The text (excluding the title page, tables and references) should not exceed 3000 words. A structured Abstract of 300 words is required and should include the following paragraphs: Background, Study Question, Data Sources, Study Design, Results, and Conclusions.

Brief Report
These are short communication of original clinical research data. The text (excluding the title page, tables and references) should not exceed 1500 words. A structured Abstract of 300 words is required and should include the following paragraphs: Background, Study Question, Methods, Results, and Conclusions.

Therapeutic Challenge
These are structured case reports organized in the following sequence: Clinical Features, Therapeutic Challenge, and Solution. The text, including up to 10 references, should not exceed 1000 words.

Systematic Review and Clinical Guidelines
These papers will address important management issues in clinical practice. The text (excluding the title page, tables and references) should not exceed 3500 words. A structured Abstract of 300 words is required and should include the following paragraphs: Background, Areas of Uncertainty, Data Sources, Results, and Conclusions.

Case Reports of adverse drug effects will be published as Letters to the Editor (maximum 3 authors, maximum 500 words including references).

Preparation of Manuscript
Manuscripts that do not adhere to the following instructions will be returned to the corresponding author for technical revision before undergoing peer review.
General format: Submit manuscripts in English. Double space all copy including legends, footnotes, tables, and references.
Title page: Include on the title page (a) complete manuscript title; (b) authors' full names, highest academic degrees, and affiliations; (c) name and address for correspondence, including fax number, telephone number, and e-mail address; (d) address for reprints if different from that of corresponding author; and (e) sources of support that require acknowledgment. The title page must also include disclosure of funding received for this work from any of the following organizations: National Institutes of Health (NIH); Wellcome Trust; Howard Hughes Medical Institute (HHMI); and other(s).
The title page must also include disclosure of funding received for this work from any of the following organizations: National Institutes of Health (NIH); Wellcome Trust; Howard Hughes Medical Institute (HHMI); and other(s).
Abbreviations: For a list of standard abbreviations, consult the Council of Biology Editors Style Guide (available from the Council of Science Editors, 9650 Rockville Pike, Bethesda, MD 20814) or other standard sources. Write out the full term for each abbreviation at its first use unless it is a standard unit of measure.
References: The authors are responsible for the accuracy of the references. Key the references (doublespaced) at the end of the manuscript. Cite the references in text in the order of appearance. Cite unpublished data, such as papers submitted but not yet accepted for publication or personal communications, in parentheses in the text. If there are more than three authors, name only the first three authors and then use et al. Refer to the List of Journals Indexed in Index Medicus for abbreviations of journal names, or access the list at http://www.nlm.nih.gov/tsd/serials/lji.html. Sample references are given below.

Journal article
1. Willens HJ. Clopidogrel-induced mixed hepatocellular and cholestatic liver injury. Am J Ther. 2000;7:317–318.

Book chapter
2. Collins JM. Regulatory viewpoint: prediction of drug interactions from in vitro studies. In: Levy RH, Thummel KE, Trager WF, et al, eds. Metabolic Drug Interactions. Philadelphia: Lippincott Williams & Wilkins, 2000:41–50.

Entire book
3. Levy RH, Thummel KE, Trager WF, et al. Metabolic Drug Interactions. Philadelphia: Lippincott Williams & Wilkins, 2000.

Software
4. Epi Info [computer program]. Version 6. Atlanta: Centers for Disease Control and Prevention, 1994.

Online journals
5. Friedman SA. Preeclampsia: a review of the role of prostaglandins. Obstet Gynecol [serial online]. January 1988;71:22-37. Available from: BRS Information Technologies, McLean, VA. Accessed December 15, 1990.

Database
6. CANCERNET-PDQ [database online]. Bethesda, MD: National Cancer Institute, 1996. Updated March 29, 1996.

World Wide Web
7. Gostin LO. Drug use and HIV/AIDS [JAMA HIV/AIDS web site]. Available at: http://www.ama-assn.org/special/hiv/ethics. Accessed June 26, 1997.

Figures:

A) Creating Digital Artwork

1 Learn about the publication requirements for Digital Artwork: http://links.lww.com/ES/A42

2 Create, Scan and Save your artwork and compare your final figure to the Digital Artwork Guideline Checklist (below).

3 Upload each figure to Editorial Manager in conjunction with your manuscript text and tables.

B) Digital Artwork Guideline Checklist
Here are the basics to have in place before submitting your digital artwork:

ØArtwork should be saved as TIFF, EPS, or MS Office (DOC, PPT, XLS) files. High resolution PDF files are also acceptable.

ØCrop out any white or black space surrounding the image.

ØDiagrams, drawings, graphs, and other line art must be vector or saved at a resolution of at least 1200 dpi. If created in an MS Office program, send the native (DOC, PPT, XLS) file.

ØPhotographs, radiographs and other halftone images must be saved at a resolution of at least 300 dpi.

ØPhotographs and radiographs with text must be saved as postscript or at a resolution of at least 600 dpi.

ØEach figure must be saved and submitted as a separate file. Figures should not be embedded in the manuscript text file.

Remember:

ØCite figures consecutively in your manuscript.

ØNumber figures in the figure legend in the order in which they are discussed.

ØUpload figures consecutively to the Editorial Manager web site and enter figure numbers consecutively in the Description field when uploading the files.

Figure legends: Legends must be submitted for all figures. They should be brief and specific, and they should appear on a separate manuscript page after the references. Use scale markers in the image for electron micrographs, and indicate the type of stain used.

Color figures: The journal accepts for publication color figures that will enhance an article.

Tables: Create tables using the table creating and editing feature of your word processing software (eg, Word, WordPerfect). Do not use Excel or comparable spreadsheet programs. Group all tables at the end of the manuscript, or supply them together in a separate file. Cite tables consecutively in the text, and number them in that order. Key each on a separate sheet, and include the table title, appropriate column heads, and explanatory legends (including definitions of any abbreviations used). Do not embed tables within the body of the manuscript. They should be self-explanatory and should supplement, rather than duplicate, the material in the text.

Supplemental Digital Content (SDC): Authors may submit SDC via Editorial Manager to LWW journals that enhance their article’s text to be considered for online posting. SDC may include standard media such as text documents, graphs, audio, video, etc. On the Attach Files page of the submission process, please select Supplemental Audio, Video, or Data for your uploaded file as the Submission Item. If an article with SDC is accepted, our production staff will create a URL with the SDC file. The URL will be placed in the call-out within the article. SDC files are not copy-edited by LWW staff, they will be presented digitally as submitted. For a list of all available file types and detailed instructions, please visit http://links.lww.com/A142.
SDC Call-outs: Supplemental Digital Content must be cited consecutively in the text of the submitted manuscript. Citations should include the type of material submitted (Audio, Figure, Table, etc.), be clearly labeled as “Supplemental Digital Content,” include the sequential list number, and provide a description of the supplemental content. All descriptive text should be included in the call-out as it will not appear elsewhere in the article.
Example:
We performed many tests on the degrees of flexibility in the elbow (see Video, Supplemental Digital Content 1, which demonstrates elbow flexibility) and found our results inconclusive.
List of Supplemental Digital Content: A listing of Supplemental Digital Content must be submitted at the end of the manuscript file. Include the SDC number and file type of the Supplemental Digital Content. This text will be removed by our production staff and not be published.
Example:
Supplemental Digital Content 1. wmv
SDC File Requirements: All acceptable file types are permissible up to 10 MBs. For audio or video files greater than 10 MBs, authors should first query the journal office for approval. For a list of all available file types and detailed instructions, please visit http://links.lww.com/A142.

Style: Pattern manuscript style after the American Medical Association Manual of Style (9th edition). Stedman's Medical Dictionary (27th edition) and Merriam Webster's Collegiate Dictionary (10th edition) should be used as standard references. Refer to drugs and therapeutic agents by their accepted generic or chemical names, and do not abbreviate them. Use code numbers only when a generic name is not yet available. In that case, supply the chemical name and a figure giving the chemical structure of the drug. Capitalize the trade names of drugs and place them in parentheses after the generic names. To comply with trademark law, include the name and location (city and state in USA; city and country outside USA) of the manufacturer of any drug, supply, or equipment mentioned in the manuscript. Use the metric system to express units of measure and degrees Celsius to express temperatures, and use SI units rather than conventional units.

The editorial office will acknowledge receipt of your manuscript and will give you a manuscript number for reference. Address all inquiries regarding manuscripts not yet accepted or published to the journal's editorial office.

Conflicts of interest: Authors must state all possible conflicts of interest in the manuscript, including financial, consultant, institutional and other relationships that might lead to bias or a conflict of interest. If there is no conflict of interest, this should also be explicitly stated as none declared. All sources of funding should be acknowledged in the manuscript. All relevant conflicts of interest and sources of funding should be included on the title page of the manuscript with the heading “Conflicts of Interest and Source of Funding:”. For example: Conflicts of Interest and Source of Funding: A has received honoraria from Company Z. B is currently receiving a grant (#12345) from Organization Y, and is on the speaker’s bureau for Organization X – the CME organizers for Company A. For the remaining authors none were declared.

Copyright Form
In addition, each author must complete and submit the journal's copyright transfer agreement, which includes a section on the disclosure of potential conflicts of interest based on the recommendations of the International Committee of Medical Journal Editors, "Uniform Requirements for Manuscripts Submitted to Biomedical Journals" (www.icmje.org/update.html).

A copy of the form is made available to the submitting author within the Editorial Manager submission process. Co-authors will automatically receive an Email with instructions on completing the form upon submission.

Patient anonymity and informed consent: It is the author's responsibility to ensure that a patient's anonymity be carefully protected and to verify that any experimental investigation with human subjects reported in the manuscript was performed with informed consent and following all the guidelines for experimental investigation with human subjects required by the institution(s) with which all the authors are affiliated. Authors should mask patients' eyes and remove patients' names from figures unless they obtain written consent from the patients and submit written consent with the manuscript.

Permissions: Authors must submit written permission from the copyright owner (usually the publisher) to use direct quotations, tables, or illustrations that have appeared in copyrighted form elsewhere, along with complete details about the source. Any permissions fees that might be required by the copyright owner are the responsibility of the authors requesting use of the borrowed material, not the responsibility of Lippincott Williams & Wilkins.

Open access
Authors of accepted peer-reviewed articles have the choice to pay a fee to allow perpetual unrestricted online access to their published article to readers globally, immediately upon publication. Authors may take advantage of the open access option at the point of acceptance to ensure that this choice has no influence on the peer review and acceptance process. These articles are subject to the journal's standard peer-review process and will be accepted or rejected based on their own merit.

The article processing charge (APC) is charged on acceptance of the article and should be paid within 30 days by the author, funding agency or institution. Payment must be processed for the article to be published open access. For a list of journals and pricing please visit our Wolters Kluwer Open Health Journals page.

Authors retain copyright
Authors retain their copyright for all articles they opt to publish open access. Authors grant Wolters Kluwer an exclusive license to publish the article and the article is made available under the terms of a Creative Commons user license. Please visit our Open Access Publication Process page for more information.

Creative Commons license
Open access articles are freely available to read, download and share from the time of publication under the terms of the Creative Commons License Attribution-NonCommerical No Derivative (CC BY-NC-ND) license. This license does not permit reuse for any commercial purposes nor does it cover the reuse or modification of individual elements of the work (such as figures, tables, etc.) in the creation of derivative works without specific permission.

Compliance with funder mandated open access policies
An author whose work is funded by an organization that mandates the use of the Creative Commons Attribution (CC BY) license is able to meet that requirement through the available open access license for approved funders. Information about the approved funders can be found here: http://www.wkopenhealth.com/inst-fund.php

FAQ for open access
http://www.wkopenhealth.com/openaccessfaq.php

After Acceptance

Electronic page proofs and corrections
Corresponding authors will receive electronic page proofs to check the copyedited and typeset article before publication. Portable document format (PDF) files of the typeset pages and support documents (e.g., reprint order form) will be sent to the corresponding author via e-mail. Complete instructions will be provided with the e-mail for downloading and marking the electronic page proofs. Corresponding author must provide an email address. The proof/correction process is done electronically.

It is the author's responsibility to ensure that there are no errors in the proofs. Authors who are not native English speakers are strongly encouraged to have their manuscript carefully edited by a native English-speaking colleague. Changes that have been made to conform to journal style will stand if they do not alter the authors' meaning. Only the most critical changes to the accuracy of the content will be made. Changes that are stylistic or are a reworking of previously accepted material will be disallowed. The publisher reserves the right to deny any changes that do not affect the accuracy of the content. Authors may be charged for alterations to the proofs beyond those required to correct errors or to answer queries. Electronic proofs must be checked carefully and corrections returned within 24 to 48 hours of receipt, as requested in the cover letter accompanying the page proofs.

Reprints. Authors will receive an email notification with a link to the order form soon after their article publishes in the journal (https://shop.lww.com/author-reprint). Reprints are normally shipped 6 to 8 weeks after publication of the issue in which the item appears. Contact the Reprint Department, Lippincott Williams & Wilkins, 351 W. Camden Street, Baltimore, MD 21201; Fax: 410.558.6234; E-mail: authorreprints@wolterskluwer.com with any questions.

Publisher's contact: Please send corrected page proofs through the Editorial Manager system using the instructions on your proof notification email.

Manuscript Checklist (before submission)

ØComplete manuscript

ØClearly labeled figures

ØCover letter

ØTitle page

ØAbstract

ØReferences double-spaced in journal style

ØCorresponding author designated, and full mailing address included, in cover letter and on title page

ØE-mail address of corresponding author included in cover letter and on title page

ØPermission to reproduce copyrighted materials or signed patient consent forms. One signed form MUST be uploaded for each author for production to begin

ØAcknowledgments listed for grants and technical support

ØCompleted "Authorship Responsibility, Disclosure, and Copyright Transfer" forms. Each author must complete, sign and return the form.

ØTables created using table software feature